I bought my Stryker 4 weeks ago & have put 1,500 miles on it my self. Mostly curvy/hilly backroads but some mix of city & hwy. Adding the boulevard windshield & Mustang seat has made the longer rides more enjoyable. My mpg has ranged from 38 to 47 but is in the low 40s most of the time.
I didn't buy the Stryker to go fast, I have other bikes for that. I'm probably in the minority in that I'm happy with the sound of the Stryker. We go on alot of 200 mile day trips & a loud exhaust beats on you after awhile (been there, done that). My biggest grip is how easy it is to scrap pegs or my boot heals. I've learned to tuck my foot in during turns & just let the ped bounce off the pavement. I'm ready for my back tire to wear so I can go to a 240 & hopefully the extra height will give me more room to lean without scrapping pegs.
I haven't hit any potholes yet but not many around by me so I haven't had any joilts to the spine while riding & have no extra ackes/pains after our 200 mile day trips. I will add that I'm in constant pain from a head on car crash 3 years ago (thanks to a new driver) so maybe the discomforts there & I can't tell.
The long wheel base/rake of the Stryker can make carving thru the hillsides a bit challenging but fun if there are too many sharp S curves back to back. That's when the wife gets a bit nervous.
Overall I'm very happy with my Stryker but for weekend trips I'm planning on getting a Kawasaki Concours 14 ABS which is what I was going to buy until I saw the Stryker. Now my lovely wife suggested that I should get both.