The thing with the car tire on a stryker.. Usually when people go and do this, they put a car tire that has a pretty similar profile as a bike tire. The stryker rim is awful wide, so when you put a car tire on it you have a huge flat surface.
That said I have a General G-Max AS-03 and I like it just fine. It looks badass, in my opinion, and I expect to get 40k+ miles out of it. I can grind the pegs all day long, but I did run into a spot of trouble one time when I was grinding the frame. I got lucky that time, but I do take it a bit easier now.
Some other down sides: I had my license plate mounted too close to it and it ate the plate and destroyed my tail light. This was my fault, clearly, but if you have modded your license plate bracket keep an eye on it. It was a good excuse to mod - looks even cooler with led tail lights and a axle mount bracket.
The other big thing is, the big flat tire will mess you up at slow speeds if the road is rough. Like pulling up to a stop at a bumpy intersection... the tire tries to stay flat and will buck you all over the place.